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Best Hotels in Otay Mesa West. Book Today!

Otay Mesa West Hotels & Places to Stay in Otay Mesa West. Find hotels in Otay Mesa West, San Diego.

From US $110

Best Western Chula Vista/Otay Valley Hotel

7.3 (1734 Reviews) Hotel

Breakfast • Free on-site parking • Outdoor swimming pool

Chula Vista Sesame Place San Diego • In Otay Mesa West · 2.5km to center

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From US $90

Motel 6-San Diego, CA - Southbay

7.9 (525 Reviews) Hotel

Free on-site parking • Pet friendly • Wifi

San Diego Nestor • In Otay Mesa West · 2.5km to center

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From US $122

Best Western Americana Inn

8.7 (969 Reviews) Hotel

Breakfast • Private parking • Outdoor swimming pool

San Diego San Ysidro • In Otay Mesa West · 2.2km to center

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From US $97

Studio 6 Suites San Ysidro CA San Diego South Bay

7.9 (1563 Reviews) Hotel

Free on-site parking • Outdoor swimming pool • Pet friendly

San Diego San Ysidro • In Otay Mesa West · 3.4km to center

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From US $74

Motel 6-San Ysidro, CA - San Diego - Border

6.6 (1365 Reviews) Hotel

Free on-site parking • Outdoor swimming pool • Pet friendly

San Diego San Ysidro • In Otay Mesa West · 3.5km to center

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From US $90

Chula Vista Inn

7.2 (205 Reviews) Hotel

Free parking • Free WiFi • Non-smoking rooms

San Diego Palm City • In Otay Mesa West · 4.8km to center

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From US $85

Valli Hi Motel

8.1 (457 Reviews) Motel

Free on-site parking • Outdoor swimming pool • Balcony

San Diego San Ysidro • In Otay Mesa West · 2.4km to center

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From US $68

Border Plaza Hotel

7.3 (133 Reviews) Hotel

Free on-site parking • Balcony • View

San Diego San Ysidro • In Otay Mesa West · 4.1km to center

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From US $75

Rodeway Inn San Diego South San Ysidro Border

10.0 (14 Reviews) Inn

Breakfast • Free on-site parking • Free WiFi

San Diego San Ysidro • In Otay Mesa West · 4.1km to center

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From US $80

ERTH INN by AGA- San Ysidro

6.6 (80 Reviews) Hotel

Free on-site parking • Outdoor swimming pool • Private bathroom

San Diego San Ysidro • In Otay Mesa West · 4.0km to center

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From US $80

Star Motel

8.8 (26 Reviews) Hotel

Free on-site parking • Free WiFi • Private bathroom

San Diego Palm City • In Otay Mesa West · 2.3km to center

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About Otay Mesa West Hotels with Suites on NearbyHoliday

Looking for hotels in Otay Mesa West? Compare top options in San Diego.

NearbyHoliday features the hottest hotel deals in Otay Mesa West, US. In addition to the best hotels and best resorts, we have many hotels that offer full hotel suites in Otay Mesa West, from budget to luxury, to suit your needs as well.

Our site boasts of more than 11 hotels listed in or near Otay Mesa West. Whether you are going on a business trip, leisure vacation with a group, or traveling with your family or friends for summer or winter break, there is always a hotel or resort perfect for you.

From beachfront hotels and all inclusive resorts, to boutique hotels and luxury rentals, we have thousands of hotels, resorts, inns, and motels with updated prices for 2026. NearbyHoliday also lists many last minute hotels and cheap hotels from many of the top travel providers, including top hotel chains such as Radisson Hotel, OYO, Marriott, Hyatt, Hilton, MGM Resorts, & more.

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Frequently Asked Questions About Hotels in Otay Mesa West

There are a lot of hotels in Otay Mesa West. If you plan on staying in the Otay Mesa West area, consider making a reservation for a few nights at one of these properties as these have been rated the top Hotels in Otay Mesa West: